Formulation and Evaluation of Niosomal Gel Loaded with Asparagus racemosus Extract for Anti-inflammatory Activity

Abstract: Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate blood. Asparagus racemosus extract contains various saponins and flavonoids plant-origin drugs have fewer side effects toxicity. The phytoconstituents less permeability through skin; to enhance their effectiveness it was loaded niosomes. Therefore, study aimed formulate characterize niosomal gel with for anti-inflammatory activity. Materials Methods: niosomes containing were prepared using thin film hydration method 23 full factorial design employed assess influence of independent variables span 60 cholesterol on vesicle size, PDI, zeta potential, percentage entrapment efficiency. 10% conventional gels by incorporating optimized total saponin 1% carbopol gel. Ex vivo studies performed goat skin Franz diffusion cell. An conducted albino rat. Results: statistical analysis revealed significant effect efficiency potential. SEM image shows vesicles are spherical shape uniform size. provided a significantly higher amount steady-state flux coefficient into than animal model proved that showed compared control. Conclusion: It concluded had better efficacy Keywords: racemosus, Niosomes, Span 60, Cholesterol, Factorial design, Carbopol 934.